RESUMO
A hundred and twenty years ago, the Butantan Institute was founded by the Brazilian physician and scientist Vital Brazil, combining, in the same institution, medical research, and the transfer of results to society in the form of health products [...].
Assuntos
Academias e Institutos/história , Toxicologia/história , Peçonhas/toxicidade , Animais , Brasil , História do Século XX , História do Século XXI , Humanos , Internacionalidade/históriaAssuntos
Síndromes Neurotóxicas/história , Toxicologia/história , Animais , Pesquisa Biomédica/história , História do Século XX , História do Século XXI , Humanos , National Institutes of Health (U.S.)/história , National Institutes of Health (U.S.)/estatística & dados numéricos , Apoio à Pesquisa como Assunto/história , Apoio à Pesquisa como Assunto/estatística & dados numéricos , Estados UnidosAssuntos
Distinções e Prêmios , Toxicologia/história , História do Século XXI , Humanos , Estados UnidosAssuntos
Toxicologia/história , Dano ao DNA , História do Século XX , História do Século XXI , Humanos , Estados UnidosRESUMO
Jean Rodier (1920-2003), distinguished researcher and scientist, directed the Toxicology Department of Hygiene Institute of Rabat under the French Protectorate. From 1946, he developed numerous lines of research in occupational health, in particular on Manganism, a neurological disorder that impacted miners in his home country of Morocco. His many papers on Manganism, only one of which was published in English, describe field and laboratory research studies that focused its prevention and management.
Assuntos
Pesquisa Biomédica/história , Intoxicação por Manganês/história , Doenças Profissionais/história , Toxicologia/história , História do Século XX , História do Século XXI , Humanos , Intoxicação por Manganês/diagnóstico , Intoxicação por Manganês/epidemiologia , Intoxicação por Manganês/prevenção & controle , Mineradores/história , Mineração/história , Marrocos/epidemiologia , Doenças Profissionais/diagnóstico , Doenças Profissionais/epidemiologia , Doenças Profissionais/prevenção & controle , Saúde Ocupacional/história , Medição de Risco , Fatores de RiscoRESUMO
David S. Miller was Acting Scientific Director of the Division of Intramural Research at the National Institute of Environmental Health Sciences, National Institutes of Health, and Head of the Intracellular Regulation Group in the Laboratory of Toxicology and Pharmacology before he retired in 2016. David received his Ph.D. in biochemistry from the University of Maine in 1973. David was a Group Leader at the Michigan Cancer Foundation before joining the NIEHS in 1985. His research covered a wide range from renal excretory transport mechanisms to regulation of transporters at the blood-CSF and blood-brain barriers, from fish, amphibians and birds to mammals. David was an outstanding scientist with irresistible enthusiasm for science and an incredible ability to think outside the box while being an exceptional mentor and friend.
Assuntos
Neurociências/história , Barreira Hematoencefálica/fisiologia , História do Século XX , História do Século XXI , Humanos , Masculino , Mentores , National Institutes of Health (U.S.) , Farmacologia/história , Transporte Proteico/fisiologia , Toxicologia/história , Estados UnidosRESUMO
To begin, I wish to thank the Academy of Toxicological Sciences for bestowing this honor on me. I have had a rewarding career in basic research and clinical medicine, beginning with research in high school and always planning on becoming a physician. I have had the good fortune of having outstanding mentors, wonderful parents, and a supportive and intuitive wife and family. This article provides a brief overview of some of the events of my career and individuals who have played a major role, beginning with the M.D./Ph.D. program at the University of Wisconsin, pathology residency and faculty at St. Vincent Hospital, Worcester, Massachusetts, a year as visiting professor at Nagoya City University, and my career at the University of Nebraska Medical Center since 1981. This could not have happened without the strong input and support from these individuals, the numerous students, residents and fellows with whom I have learned so much, and the more than 500 terrific collaborators.
Assuntos
Distinções e Prêmios , Oncologia/história , Toxicologia/história , Pesquisa Biomédica , História do Século XX , História do Século XXI , Medição de RiscoRESUMO
For the past five years, Dr. Daniel Acosta has served as the Deputy Director of Research at the National Center for Toxicological Research (NCTR), a principle research laboratory of the U.S. Food and Drug Administration (FDA). Over his career at NCTR, Dr. Acosta has had a major impact on developing and promoting the use of in vitro assays in regulatory toxicity and product safety assessments. As Dr. Acosta nears his retirement we have dedicated this paper to his many accomplishments at the NCTR. Described within this paper are some of the in vitro studies that have been conducted under Dr. Acosta's leadership. These studies include toxicological assessments involving developmental effects, and the development and application of in vitro reproductive, heart, liver, neurological and airway cell and tissue models.
Assuntos
Testes de Toxicidade/história , Toxicologia/história , Animais , Pesquisa Biomédica/história , História do Século XX , História do Século XXI , Desenvolvimento Humano , Humanos , Modelos Biológicos , Estados Unidos , United States Food and Drug AdministrationRESUMO
This year we turn 70! Lucky for journals, they don't get old with volumes. In our case, quite the opposite. The idea of this editorial, however, is not to look so far back but to share with you - our readers and authors - where we see Archives in the years to come.